Outcome of cycles of oocyte in vitro maturation requiring testicular sperm extraction for nonobstructive azoospermia

Abstract
Objective: To assess the applicability of oocyte IVM in case of nonobstructive azoospermia (NOA).
Result(s): Twenty-seven IVM-TESE cycles were carried out in 21 women. Fertilization rate was 64.4%. In compliance with national legislation, no more than three oocytes were inseminated in each cycle and all developing embryos were transferred. Six single clinical pregnancies were ascertained (22.2% and 27.3% pregnancy rates per cycle and per transfer, respectively). One pregnancy ended in abortion. The others developed to term and gave rise to five healthy babies. Sixty couples underwent standard COS-TESE treatment. Rates of fertilization, clinical pregnancy per cycle, implantation, and abortion were 64.6%, 20.0%, 11.3%, and 16.7%, respectively. Eleven babies were born from ten pregnancies.
Conclusion(s):Oocyte IVM may represent an option in NOA cases.

Autori: Rubens Fadini, Elisabetta Colpi, Mario Mignini Renzini, Giovanni Coticchio, Ruggero Comi, Massimo Mastrolilli, Teresa Guarnieri, Annalisa Villa, Mariabeatrice Dal Canto