Clinical efficiency and perinatal outcome of ART cycles following embryo culture in the presence of GM-CSF in patients with miscarriage or early pregnancy loss history

Abstract
Study question: To evaluate, in IVF patients presenting with a history of previous micscarriage or biochemical pregnancy, the clinical efficiency and perinatal outcome of assisted reproduction cycles in which embryos were cultured in Embryogen® (EG), a commercially available medium containing granulocyte macrophage-colony stimulation factor (GM-CSF).
Main results and the role of chance: Mean number of inseminated oocytes and replaced embryos were comparable. Clinical pregnancy rates per transfer were similar, 20.3% (29/143) and 18.8% (36/192) respectively, in the EG and control groups. However, at the 12th gestational week, a lower abortion rate was observed in the EG group (13.8% vs. 44.4%), resulting in a higher live birth rate per recovery (19.5% vs. 9.5%). EG pregnancies resulted in 18 single, 4 twin and 1 triplet deliveries, while 17 single and 2 twin births were achieved in the control group. In single births, gestational age and birth weight were 37.8 ± 1.8 vs. 36.4 ± 3.2 weeks and 3068.5± 461.8 vs. 2801.4 ± 632.6 g, in control and treatment groups, respectively. No major or minor birth abnormalities were detected.

Autori: Mignini Renzini M., Dal Canto M., Coticchio G., Comi R., Brigante C., Caliari I., Brambillasca F., Merola M., Lain M., Turchi D.