Oocyte in vitro maturation in normo-ovulatory women

Abstract
Objective: To review the scientific literature concerning the application of oocyte in vitro maturation (IVM) as a treatment for normo-ovulatory women.
Results: Maturation rates in vitro are suboptimal and influenced by several factors. IVM oocytes fertilize and undergo development in vitro with rates similar to in vivo matured control oocytes. In IVM cycles implantation and pregnancy rates are lower compared with controlled ovarian stimulation treatments, but accurate patient selection can improve IVM clinical outcome.
Conclusion: In normal responders, IVM does not reach success rates similar to conventional ovarian stimulation regimens. However, it represents a milder approach to assisted reproduction treatment and an alternative intervention for specific conditions.

Autori: Rubens Fadini, Mario Mignini Renzini, Mariabeatrice Dal Canto, Amalia Epis, Marilena Crippa, Ilaria Caliari, Claudio Brigante, Giovanni Coticchio